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dc.creatorGutiérrez, José María
dc.creatorSamuel, Stephen P.
dc.creatorHerrera Vega, María
dc.creatorBryan Quirós, Wendy
dc.creatorLomonte, Bruno
dc.creatorBickler, Philip E.
dc.creatorBulfone, Tommaso C.
dc.creatorWilliams, David J.
dc.date.accessioned2019-01-15T15:57:23Z
dc.date.available2019-01-15T15:57:23Z
dc.date.issued2018
dc.identifier.citationhttps://www.mdpi.com/2072-6651/10/10/380es_ES
dc.identifier.issn2072-6651
dc.identifier.urihttp://hdl.handle.net/10669/76387
dc.description.abstractThere is an unmet need for economical snakebite therapies with long shelf lives that are effective even with delays in treatment. The orally bioavailable, heat-stable, secretory phospholipase A2 (sPLA2) inhibitor, LY333013, demonstrates antidotal characteristics for severe snakebite envenoming in both field and hospital use. A murine model of lethal envenoming by a Papuan taipan (Oxyuranus scutellatus) demonstrates that LY333013, even with delayed oral administration, improves the chances of survival. Furthermore, LY333013 improves the performance of antivenom even after it no longer reverses neurotoxic signs. Our study is the first demonstration that neurotoxicity from presynaptic venom sPLA2S can be treated successfully, even after the window of therapeutic antivenom has closed. These results suggest that sPLA2 inhibitors have the potential to reduce death and disability and should be considered for the initial and adjunct treatment of snakebite envenoming. The scope and capacity of the sPLA2 inhibitors ability to achieve these endpoints requires further investigation and development effortses_ES
dc.language.isoen_USes_ES
dc.rightsCC BY 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.sourceToxins, vo.10(10), pp. 1-7.es_ES
dc.subjectSnakebitees_ES
dc.subjectEnvenominges_ES
dc.subjectNeglected tropical diseasees_ES
dc.subjectField antidotees_ES
dc.subjectInhibitores_ES
dc.subjectTaipanes_ES
dc.subjectPLA2es_ES
dc.subjectPhospholipase A2es_ES
dc.subjectNeurotoxicityes_ES
dc.subjectAntivenomes_ES
dc.subject615.94 Venenos animaleses_ES
dc.titleDelayed oral LY333013 rescues mice from highly neurotoxic, lethal doses of Papuan Taipan (Oxyuranus scutellatus) venomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.3390/toxins10100380
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Docencia::Salud::Facultad de Microbiologíaes_ES


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CC BY 4.0 International
Except where otherwise noted, this item's license is described as CC BY 4.0 International