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dc.creatorGonzález Espinoza, Gabriela
dc.creatorBarquero Calvo, Elías
dc.creatorLizano González, Esteban
dc.creatorAlfaro Alarcón, Alejandro
dc.creatorArias Gómez, Berny
dc.creatorChaves Olarte, Esteban
dc.creatorLomonte, Bruno
dc.creatorMoreno, Edgardo
dc.creatorChacón Díaz, Carlos
dc.date.accessioned2019-01-15T16:04:54Z
dc.date.available2019-01-15T16:04:54Z
dc.date.issued2018
dc.identifier.citationhttps://iai.asm.org/content/86/10/e00567-18.longes_ES
dc.identifier.issn1098-5522
dc.identifier.urihttp://hdl.handle.net/10669/76388
dc.description.abstractBrucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement. Since complement stands as the first line of defense during bacterial invasions, we explored the role of complement in B. abortus infections. Brucella abortus-infected mice depleted of complement with cobra venom factor (CVF) showed the same survival rate as mice in the control group. The complement-depleted mice readily eliminated B. abortus from the spleen and did so more efficiently than the infected controls after 7 days of infection. The levels of the proinflammatory cytokines tumor necrosis factor alpha and interleukin-6 (IL-6) remained within background levels in complement-depleted B. abortus-infected mice. In contrast, the levels of the immune activator cytokine gamma interferon and the regulatory cytokine IL-10 were significantly increased. No significant histopathological changes in the liver and spleen were observed between the complement-depleted B. abortus-infected mice and the corresponding controls. The action exerted by Brucella on the immune system in the absence of complement may correspond to a broader phenomenon that involves several components of innate immunity.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[803-B0-601]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[803-B8-762]/UCR/Costa Ricaes_ES
dc.description.sponsorshipInternational Centre for Genetic Engineering and Biotechnology/[CRP/16/005]/ICGBE/Argentinaes_ES
dc.language.isoen_USes_ES
dc.sourceInfection and Immunity, vol.86(10), pp. 1-8.es_ES
dc.subjectBrucellaes_ES
dc.subjectBrucella abortuses_ES
dc.subjectBrucellosises_ES
dc.subjectComplementes_ES
dc.subjectCobra venom factores_ES
dc.subjectInnate immunityes_ES
dc.subject619.93 Roedores y conejoses_ES
dc.titleDepletion of complement enhances the clearance of Brucella abortus in micees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1128/IAI.00567-18
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET)es_ES
dc.description.procedenceUCR::Docencia::Salud::Facultad de Microbiologíaes_ES
dc.identifier.codproyecto803-B0-601
dc.identifier.codproyecto803-B8-762


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