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dc.creatorMurray, Christopher M.
dc.creatorEaster, Michael
dc.creatorMerchant, Mark
dc.creatorRheubert, Justin L.
dc.creatorWilson, Kelly A.
dc.creatorCooper, Amos
dc.creatorMendonça, Mary
dc.creatorWibbels, Thane
dc.creatorSasa Marín, Mahmood
dc.creatorGuyer, Craig
dc.date.accessioned2019-04-05T15:24:58Z
dc.date.available2019-04-05T15:24:58Z
dc.date.issued2016-07-09
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0016648016302040#!es_ES
dc.identifier.issn0016-6480
dc.identifier.urihttps://hdl.handle.net/10669/76861
dc.description.abstractEffects of xenobiotics can be organizational, permanently affecting anatomy during embryonic development, and/or activational, influencing transitory actions during adulthood. The organizational influence of endocrine-disrupting contaminants (EDC’s) produces a wide variety of reproductive abnormalities among vertebrates that exhibit temperature-dependent sex determination (TSD). Typically, such influences result in subsequent activational malfunction, some of which are beneficial in aquaculture. For example, 17-amethyltestosterone (MT), a synthetic androgen, is utilized in tilapia farming to bias sex ratio towards males because they are more profitable. A heavily male-biased hatchling sex ratio is reported from a crocodile population near one such tilapia operation in Guanacaste, Costa Rica. In this study we test the effects of MT on sexual differentiation in American alligators, which we used as a surrogate for all crocodilians. Experimentally, alligators were exposed to MT in ovo at standard ecotoxicological concentrations. Sexual differentiation was determined by examination of primary and secondary sex organs post hatching. We find that MT is capable of producing male embryos at temperatures known to produce females and demonstrate a dose-dependent gradient of masculinization. Embryonic exposure to MT results in hermaphroditic primary sex organs, delayed renal development and masculinization of the clitero-penis (CTP).es_ES
dc.language.isoen_USes_ES
dc.sourceGeneral and Comparative Endocrinology, vol. 236, pp. 63-69es_ES
dc.subjectMethyltestosteronees_ES
dc.subjectTemperature-dependent sex determinationes_ES
dc.subjectAndrogenes_ES
dc.subjectCrocodilianes_ES
dc.subject597.98 Crocodilia (Cocodrilos)es_ES
dc.titleMethyltestosterone alters sex determination in the American alligator (Alligator mississippiensis)es_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/j.ygcen.2016.07.007
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologíaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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