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dc.creatorSteinbrueck, Clara
dc.creatorMora Ugalde, Nohelia
dc.creatorMorales Sánchez, Carlos
dc.creatorLoaiza Montoya, Randall
dc.creatorGarcía Piñeres, Alfonso J.
dc.creatorAraya Barrantes, Juan José
dc.date.accessioned2019-08-14T19:12:35Z
dc.date.available2019-08-14T19:12:35Z
dc.date.issued2019
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S1874390018302556#!es_ES
dc.identifier.issn1874-3900
dc.identifier.urihttp://hdl.handle.net/10669/78890
dc.description.abstractBioassay-guided fractionation of Acnistus arborescens (Solanaceae) organic extract afforded two anti-inflammatory withanolides: 2,3-Dihydro-3β-O-sulfate withacnistin (1) and 2,3-Dihydro-3β-O-sulfate withaferin A (2) showing IC50 values of 1.0 ± 0.1 and 14 ± 1 μM respectively in a LPS-stimulated RAW 264.7 murine macrophage assay. These compounds were also evaluated against two selected cancer cell lines showing significant cytotoxicity. Although there are several reports dealing with the chemistry of this species, we report for the first time the isolation of O-sulfated withanolides.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[ 801-B8-511]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.relation.ispartof
dc.sourcePhytochemistry Letters, vol 29, pp. 190-194es_ES
dc.subjectAcnistus arborescenses_ES
dc.subjectAnti-inlammatoryes_ES
dc.subjectSulfated withanolideses_ES
dc.subjectCytotoxicityes_ES
dc.titleBioassay-guided isolation of anti-inflammatory O-sulfated withanolides from Acnistus arborescens (Solanaceae)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2019-08-06T16:38:55Z
dc.identifier.doi10.1016/j.phytol.2018.12.001
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologíaes_ES
dc.identifier.codproyecto801-B8-511


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