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dc.creatorContreras Rojas, Javier
dc.creatorHare, Elizabeth
dc.creatorChavarría Molina, Guadalupe
dc.creatorRaventós Vorst, Henriette
dc.date.accessioned2019-09-03T17:03:15Z
dc.date.available2019-09-03T17:03:15Z
dc.date.issued2017
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0165032717306493es_ES
dc.identifier.issn0165-0327
dc.identifier.urihttp://hdl.handle.net/10669/78947
dc.description.abstractBackground:Bipolar disorder type I (BPI) affects approximately 1% of the world population. Although geneticinfluences on bipolar disorder are well established, identification of genes that predispose to the illness has beendifficult. Most genetic studies are based on categorical diagnosis. One strategy to overcome this obstacle is theuse of quantitative endophenotypes, as has been done for other medical disorders.Methods:We studied 619 individuals, 568 participants from 61 extended families and 51 unrelated healthycontrols. The sample was 55% female and had a mean age of 43.25 (SD 13.90; range 18–78).Heritability and genetic correlation of the trait scale from the Anxiety State and Trait Inventory (STAI) wascomputed by using the general linear model (SOLAR package software).Results:we observed that anxiety trait meets the following criteria for an endophenotype of bipolar disorder typeI (BPI): 1) association with BPI (individuals with BPI showed the highest trait score (F = 15.20 [5,24], p =0.009), 2) state-independence confirmed after conducting a test-retest in 321 subjects, 3) co-segregation withinfamilies 4) heritability of 0.70 (SE: 0.060), p = 2.33 × 10–14and 5) genetic correlation with BPI was 0.20, (SE= 0.17, p = 3.12 × 10−5).Limitations:Confounding factors such as comorbid disorders and pharmacological treatment could affect theclinical relationship between BPI and anxiety trait. Further research is needed to evaluate if anxiety traits arespecially related to BPI in comparison with other traits such as anger, attention or response inhibition deficit,pathological impulsivity or low self-directedness.Conclusions:Anxiety trait is a heritable phenotype that follows a normal distribution when measured not only insubjects with BPI but also in unrelated healthy controls. It could be used as an endophenotype in BPI for theidentification of genomic regions with susceptibility genes for this disorderes_ES
dc.description.sponsorshipNational Institute of Mental Health/[1R01TW008290-01A]/NIMH/Estados Unidoses_ES
dc.language.isoen_USes_ES
dc.sourceJournal of Affective Disorders, vol 225 (1), pp. 395-398es_ES
dc.subjectBipolar disorderes_ES
dc.subjectEndophenotypees_ES
dc.subjectGeneticses_ES
dc.subjectHeritabilityes_ES
dc.subjectAnxietyes_ES
dc.subjectCentral Valley of Costa Ricaes_ES
dc.subject572.8 Genética bioquímicaes_ES
dc.titleQuantitative genetic analysis of anxiety trait in bipolar disorderes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/j.jad.2017.08.023
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologíaes_ES


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