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dc.creatorRamos Esquivel, Allan Eduardo
dc.creatorCordero García, Eugenia
dc.creatorBrenes Redondo, Dennis
dc.creatorAlpízar Alpízar, Warner
dc.date.accessioned2019-10-22T15:19:08Z
dc.date.available2019-10-22T15:19:08Z
dc.date.issued2018-07-13
dc.identifier.citationhttps://link.springer.com/article/10.1007/s12029-018-0134-zes_ES
dc.identifier.urihttp://hdl.handle.net/10669/79666
dc.description.abstractIntroduction High values of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are related with poor prognosis in patients with gastric cancer. However, this association has been rarely assessed in Hispanic populations that show important clinicopathological differences to Asian and Caucasian patients. In this study, we determined the prognostic value of these biomarkers in Hispanic patients from Costa Rica. Materials and Methods We retrieved data regarding pre-treatment NLR and PLR, as well as clinical variables from medical records of 381 consecutive gastric cancer patients treated in four major hospitals in Costa Rica between 2009 and 2012. Univariate and multiple Cox regression analyses were performed to assess the value of NLR and PLR as predictors of overall survival (OS) and disease-free survival (DFS). The best cutoff point was based on the maximization of the Log-rank test. Results Median follow-up was 13.21 months. In univariate analysis, a NLR ≥ 5 was associated with reduced DFS (hazard ratio (HR) 2.31; 95% confidence interval (CI) 1.78–3.00; p < 0.001) and poor OS (HR 2.24; 95% CI 1.72–2.92; p < 0.001). Similarly, a PLR ≥ 350 was associated with worse DFS (HR 2.28; 95% CI 1.70–3.06; p < 0.001) and poor OS (HR 2.33; 95% CI 1.73–3.13; p < 0.001). After adjustment for potential confounders, multivariate analysis revealed that only the NLR ≥ 5 was independently associated with worse DFS (HR 1.97; 95% CI 1.44–2.47) and OS (HR 1.59; 95%CI 1.15–2.28). Conclusions NLR ≥ 5 was independently associated with worse OS and DFS in Hispanic patients with gastric cancer.es_ES
dc.language.isoen_USes_ES
dc.sourceJournal of Gastrointestinal Cancer, 10.1007/s12029-018-0134-zes_ES
dc.subjectgastric canceres_ES
dc.subjectLymphocytees_ES
dc.subjectNeutrophiles_ES
dc.subjectPlateletes_ES
dc.subjectPrognosises_ES
dc.titleThe Neutrophil-Lymphocyte Ratio is an Independent Prognostic Factor for Overall Survival in Hispanic Patients with Gastric Adenocarcinomaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Estructuras Microscópicas (CIEMIC)es_ES


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