Show simple item record

dc.creatorde la Rosa, Guillermo
dc.creatorOlvera, Felipe
dc.creatorArchundia, Irving G.
dc.creatorLomonte, Bruno
dc.creatorAlagón Cano, Alejandro
dc.creatorCorzo, Gerardo
dc.date.accessioned2020-01-28T19:33:15Z
dc.date.available2020-01-28T19:33:15Z
dc.date.issued2019
dc.identifier.citationhttps://www.nature.com/articles/s41467-019-11639-2es_ES
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/10669/80380
dc.description.abstractAntivenoms are fundamental in the therapy for snakebites. In elapid venoms, there are toxins, e.g. short-chain α-neurotoxins, which are quite abundant, highly toxic, and consequently play a major role in envenomation processes. The core problem is that such α-neurotoxins are weakly immunogenic, and many current elapid antivenoms show low reactivity towards them. We have previously developed a recombinant consensus short-chain α-neurotoxin (ScNtx) based on sequences from the most lethal elapid venoms from America, Africa, Asia, and Oceania. Here we report that an antivenom generated by immunizing horses with ScNtx can successfully neutralize the lethality of pure recombinant and native short-chain α-neurotoxins, as well as whole neurotoxic elapid venoms from diverse genera such as Micrurus, Dendroaspis, Naja, Walterinnesia, Ophiophagus and Hydrophis. These results provide a proof-ofprinciple for using recombinant proteins with rationally designed consensus sequences as universal immunogens for developing next-generation antivenoms with higher effectiveness and broader neutralizing capacity.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-B7-608]/UCR/Costa Ricaes_ES
dc.description.sponsorshipDireccion General de Asuntos del Personal Academico/[IN203118]/DGAPA/Méxicoes_ES
dc.description.sponsorshipDireccion General de Asuntos del Personal Academico/[IN207218]/DGAPA/Méxicoes_ES
dc.language.isoen_USes_ES
dc.sourceNature Communications, vol.10, pp.1-8es_ES
dc.subjectAntivenomes_ES
dc.subjectToxinses_ES
dc.subjectsnake venomes_ES
dc.titleHorse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous specieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1038/s41467-019-11639-2
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-B7-608


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record