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dc.creatorCornelis, Marilyn C.
dc.creatorEl-Sohemy, Ahmed
dc.creatorCampos Núñez, Hannia
dc.date.accessioned2020-06-26T20:24:44Z
dc.date.available2020-06-26T20:24:44Z
dc.date.issued2007
dc.identifier.citationhttps://academic.oup.com/ajcn/article/86/3/752/4649482?searchresult=1es_ES
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.urihttps://hdl.handle.net/10669/81223
dc.description.abstractBackground: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of α-linolenic acid (ALA), the metabolic precursor of EPA and DHA, has not been studied. The Δ6-desaturase enzyme converts ALA into EPA and DHA, and genetic variation in the Δ6-desaturase gene (FADS2) may affect this conversion. Objectives: We hypothesize that high ALA is associated with a lower prevalence of the metabolic syndrome and that genetic variation in FADS2 modifies this association. Design: We studied 1815 Costa Rican adults. Adipose tissue ALA was used as a biomarker of intake, and metabolic syndrome was identified with the definition from the National Cholesterol Education Program, Adult Treatment Panel III. Prevalence ratios (PRs) and 95% CIs were estimated from binomial regression models, and the likelihood ratio was used to test for effect modification. Results: High concentrations of adipose tissue ALA were associated with lower PRs of the metabolic syndrome compared with low ALA (0.81; 95% CI: 0.66, 1.00, for the comparison between the highest and the lowest quintiles; P for trend < 0.02). Higher concentrations of adipose tissue ALA were associated with a lower PR among homozygote (0.67; 95% CI: 0.53, 0.86) and heterozygote (0.84; 95% CI: 0.72, 0.99) carriers of the FADS2 T allele, but not among homozygote carriers of the deletion variant allele (0.99; 95% CI: 0.78, 1.27; P for interaction: 0.08). Conclusions: Elevated ALA concentrations in adipose tissue are associated with lower prevalence of the metabolic syndrome. A lack of association among homozygote carriers of the FADS2 deletion allele suggests that this association may be due in part to the conversion of ALA into EPA.es_ES
dc.language.isoen_USes_ES
dc.sourceThe American Journal of Clinical Nutrition, vol.86(3), pp.920-925es_ES
dc.subjectEnfermedades cardiovasculareses_ES
dc.subjectDietaes_ES
dc.subjectGenéticaes_ES
dc.subjectVegetaleses_ES
dc.subjectAlleleses_ES
dc.subjectMetabolic syndrome xes_ES
dc.subjectAdultes_ES
dc.subjectBiological markerses_ES
dc.subjectGeneses_ES
dc.subjectHeterozygotees_ES
dc.subjectHomozygotees_ES
dc.subjectAdipose tissuees_ES
dc.subjectGeneticses_ES
dc.titleGSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarctiones_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1093/ajcn/86.3.752
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP)es_ES


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