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dc.creatorMalespín Bendaña, Wendy Karina
dc.creatorMachado, José Carlos
dc.creatorUne, Clas Allan
dc.creatorAlpízar Alpízar, Warner
dc.creatorMolina Castro, Silvia Elena
dc.creatorRamírez Mayorga, Vanessa
dc.date.accessioned2022-05-04T20:53:30Z
dc.date.available2022-05-04T20:53:30Z
dc.date.issued2021-01
dc.identifier.citationhttps://www.amjmedsci.org/article/S0002-9629(21)00040-9/fulltextes_ES
dc.identifier.issn1538-2990
dc.identifier.urihttps://hdl.handle.net/10669/86542
dc.description.abstractBackground: Costa Rica is ranked as one of the countries with highest incidence of gastric cancer worldwide. Previous studies in Costa Rican populations have revealed associations between gastric cancer risk and several cytokine polymorphisms that seem to play a role in the regulation of the expression of these proteins. In this study, we assessed associations of the polymorphisms IL-6-174 G/C, IFNGR1-56 C/T, IL-8-251 T/A and TNF-A (-857 C/T, -308 A/G) with gastric pathologies in a high-risk population of Latin America. Methods: DNA samples of 47 patients with gastric adenocarcinoma, 53 with chronic gastritis, 56 with duodenal ulcer and 94 healthy controls, were genotyped for the five mentioned SNPs. All participants were ≥50-years-old. Genotyping was performed by PCR-RFLP and 5’-nuclease PCR assay. H. pylori infection, CagA status, pepsinogen (PG) I and II blood levels were determined by ELISA. Logistic regression analysis was used to determine possible associations of the polymorphisms with cancer, gastritis and duodenal ulcer, and linear regression analysis to determine associations with blood PG levels. Results: A total of 86.6% of the population was positive for H. pylori; of them, 51.6% was CagA+. Patients with the TNF-A857*T allele had an increased risk for gastritis (OR: 3.67, p = 0.015) and gastric adenocarcinoma (OR:6.15, p = 0.001). Associations between other polymorphisms and gastric diseases, or PG levels, were not found. Conclusions: Our results indicate that the TNF-A-857*T SNP is among the risk factors associated with the risk of gastric cancer in Costa Ricaes_ES
dc.language.isoenges_ES
dc.sourceAmerican Journal of the Medical Sciences, vol.362(2), pp.182-187.es_ES
dc.subjectPolymorphismes_ES
dc.subjectCosta Ricaes_ES
dc.subjectGastric Adenocarcinomaes_ES
dc.titleThe TNF-A–857*T polymorphism is associated with gastric adenocarcinoma risk in a Costa Rican populationes_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/j.amjms.2021.01.017
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Estructuras Microscópicas (CIEMIC)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Nutriciónes_ES


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