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dc.creatorSequeira Cordero, Andrey
dc.creatorMora Gallegos, Andrea
dc.creatorCuenca Berger, Patricia
dc.creatorFornaguera Trías, Jaime
dc.date.accessioned2013-11-22T19:33:24Z
dc.date.available2013-11-22T19:33:24Z
dc.date.issued2013
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0166432813003252es
dc.identifier.issn1872-7549
dc.identifier.issn0166-4328
dc.identifier.urihttp://hdl.handle.net/10669/8918
dc.descriptionartículo científico (arbitrado)--Universidad de Costa Rica, 2013. Este documento es privado debido a limitaciones de derechos de autor.es
dc.description.abstractThe study of individual differences provides an important methodological approach to analyze the neurobehavioral spectrum of a given cohort in order to understand brain function and disease. Based on immobility time in the forced swimming test (FST) juvenile and adult rats were classified as subgroups with low and high immobility. Afterwards, we compared behavior, neurochemical parameters, and gene expression profiles in some brain areas of rats with low and high immobility only. No differences in the open field test (OFT) were observed between subgroups. Regarding neurochemistry, juvenile animals with low immobility showed higher accumbal dopamine turnover and lower hippocampal norepinephrine concentrations, whereas adult rats only differed for accumbal dopamine, although in an opposite direction from that observed in juveniles. Moreover, the expression of accumbal corticotrophinreleasing factor receptor 1 (CRFR1) was significantly different in animals with low and high immobility at both ages, with animals less immobile showing higher levels of CRFR1 mRNA levels. Taken together, our findings suggest that differences in monoaminergic neurotransmission and CRFR1 expression are associated with the coping strategy adopted by the animal and with the tendency to develop depressionrelated behaviors. Concerning monoaminergic neurotransmission such association is modulated by age, and such modulation could be related to the differential behavioral results observed between juvenile and adult rats.es
dc.description.sponsorshipUniversidad de Costa Rica/[VI-742-A9-120]/UCR/Costa Rica
dc.description.sponsorshipConsejo Nacional para Investigaciones Científicas y Tecnológicas/[FI-293-2009]/CONICIT/Costa Rica
dc.language.isoen_USes
dc.publisherBehavioural Brain Research, Vol. 252. pp. 77-87es
dc.subjectNeurotransmisores
dc.subjectRataes
dc.subjectEdades
dc.subjectLimitación de la movilidades
dc.subjectIndividual difference
dc.subjectAge
dc.subjectForced swimming test
dc.subjectMonoamine
dc.subjectCRFR1
dc.titleIndividual differences in the immobility behavior in juvenile and adult rats are associated with monoaminergic neurotransmission and with the expression of corticotropin-releasing factor receptor 1 in the nucleus accumbenses
dc.typeinfo:eu-repo/semantics/articlees
dc.typeArtículo científicoes
dc.identifier.doi10.1016/j.bbr.2013.05.046
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicina
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)


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