Show simple item record

dc.creatorSilva de la Fuente, Sandra Maria
dc.creatorEscamilla, Michael
dc.creatorOntiveros, Humberto
dc.creatorMendoza Rodríguez, Ricardo
dc.creatorMuñoz, Rodrigo
dc.creatorRaventós Vorst, Henriette
dc.creatorCampos Sánchez, Rebeca
dc.creatorBarrantes Mesén, Ramiro
dc.date.accessioned2014-02-18T17:46:27Z
dc.date.available2014-02-18T17:46:27Z
dc.date.issued2006
dc.identifier.issn0018-7143
dc.identifier.issn1534-6617
dc.identifier.urihttp://hdl.handle.net/10669/9010
dc.descriptionartículo (arbitrado). Universidad de Costa Rica, Centro de Investigación Celular y Molecular, 2006es
dc.description.abstractTwo hundred seventeen male subjects from Costa Rica, Mexico, and the Hispanic population of the southwestern United States were studied. Twelve Y-chromosome STRs and the HVSI sequence of the mtDNA were analyzed to describe their genetic structure and to compare maternal and paternal lineages. All subjects are part of two NIMH-funded studies to localize schizophrenia susceptibility genes in Hispanic populations of Mexican and Central American ancestry. We showed that these three populations are similar in their internal genetic characteristics, as revealed by analyses of mtDNA and Y-chromosome STR diversity. These populations are related through their maternal lineage in a stronger way than through their paternal lineage, because a higher number of shared haplotypes and polymorphisms are seen in the mtDNA (compared to Y-chromosome STRs). These results provide evidence of previous contact between the three populations and shared histories. An analysis of molecular variance revealed no genetic differentiation for the mtDNA for the three populations, but differentiation was detected in the Y-chromosome STRs. Genetic distance analysis showed that the three populations are closely related, probably as a result of migration between close neighbors, as indicated by shared haplotypes and their demographic histories. This relationship could be an important common feature for genetic studies in Latin American and Hispanic populations.es
dc.description.sponsorshipUniversidad de Costa Ricaes
dc.language.isoen_USes
dc.publisherHuman Biology, October 2006, v. 78, no. 5, pp. 551–563.es
dc.rightsCC0 1.0 Universal*
dc.subjectEstructura genéticaes
dc.subjectEsquizofreniaes
dc.subjectAmérica Latinaes
dc.subjectCromosoma Yes
dc.titleGenetic Structure Analysis of Three Hispanic Populations from Costa Rica, Mexico, and the Southwestern United States Using Y-Chromosome STR Markers and mtDNA Sequenceses
dc.typeArtículo científicoes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttp://dx.doi.org/10.1353/hub.2007.0002
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record