Adjudicating Neurocognitive Endophenotypes for Schizophrenia
Peralta, Juan Manuel
Nicolini Sánchez, José Humberto
Glahn, David C.
Pereira Castro, Mariana
Raventós Vorst, Henriette
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Although genetic influences on schizophrenia are well established, localization of the genes responsible for this illness has proven extremely difficult. Given evidence that genes predisposing to schizophrenia may be transmitted without expression of the clinical phenotype, efforts have focused on developing endophenotypes. While several neuropsychological measures have been proposed to be endophenotypes, few studies have systematically assessed batteries of neurocognitive tests to determine which tests are most sensitive to liability for the illness. Two hundred sixty-nine Latino individualswere administered a standard neuropsychological battery.Neurocognitive measures found to be heritable were entered into analyses designed to determine which tests covary with the degree of genetic relationship to affected individuals
artículo (arbitrado) -- Universidad de Costa Rica. Centro de Investigación de Biología Celular y Molecular, 2007. Este documento es privado debido a limitaciones de derechos de autor.