Microbiología
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Clinical profiles at the time of diagnosis of COVID-19 in Costa Rica during the pre-vaccination period using a machine learning approach
(2021)Background: The clinical manifestations of COVID-19 disease, caused by the SARS-CoV-2 virus, define a large spectrum of symptoms that are mainly dependent on the human host conditions. In Costa Rica, almost 319 000 cases ... -
Two-dimensional gel electrophoresis (2D-GE) image analysis based on CellProfiler: Pseudomonas aeruginosa AG1 as model
(2020)Two-dimensional gel electrophoresis (2D-GE) is an indispensable technique for the study of proteomes of biological systems, providing an assessment of changes in protein abundance under various experimental conditions. ... -
Predicting Cancer Chemosensitivity Based on Intensity/Distribution Profiles of Cells Loaded with a Fluorescent Sphingolipid Analogue
(2018)Cancer is a group of heterogeneous and complex diseases, with limited therapeutic options due to the recurrent emergence of drug resistance. Sphingolipids are bioactive molecules that participate in signaling of cell ... -
Hybrid mathematical modeling decodes the complexity of sphingolipid pathway to predict chemosensitivity
(2017)Sphingolipid (SL) signaling pathway is a complex biological system able to integrate different types of cellular stress signals related to induction of cell death pathways with special interest in cancer. This makes of ... -
Characterization of heterogeneous response to chemotherapy by perturbation-based modeling of fluorescent sphingolipid metabolism in cancer cell subpopulations
(2017)Cancer treatments options are limited by the generation of therapy resistance, which is due by intratumoral heterogeneity in cell response. The study of resistance requires biosensors able to report the response at the ... -
A hybrid mathematical modeling approach of the metabolic fate of a fluorescent sphingolipid analogue to predict cancer chemosensitivity
(2018-06)Sphingolipid (SL) metabolism is a complex biological system that produces and transforms ceramides and other molecules able to modulate other cellular processes, including survival or death pathways key to cell fate ... -
Genomic context of the two integrons of ST-111 Pseudomonas aeruginosa AG1: A VIM-2-carrying old-acquaintance and a novel IMP-18-carrying integron
(2021)Pseudomonas aeruginosa is an opportunist and versatile organism responsible for infections mainly in immunocompromised hosts. This pathogen has high intrinsic resistance to most antimicrobials. P. aeruginosa AG1 (PaeAG1) ... -
Set-theory based benchmarking of three different variant callers for targeted sequencing
(2021)Background: Next generation sequencing (NGS) technologies have improved the study of hereditary diseases. Since the evaluation of bioinformatics pipelines is not straightforward, NGS demands efective strategies to analyze ... -
A first perturbome of Pseudomonas aeruginosa: Identification of core genes related to multiple perturbations by a machine learning approach
(2021)Tolerance to stress conditions is vital for organismal survival, including bacteria under specific environmental conditions, antibiotics, and other perturbations. Some studies have described common modulation and shared genes ... -
Molecular Determinants of Antibiotic Resistance in the Costa Rican Pseudomonas aeruginosa AG1 by a Multi-omics Approach: A Review of 10 Years of Study
(2021)Pseudomonas aeruginosa AG1 (PaeAG1) is a Costa Rican strain that was isolated in 2010 in a major Hospital. This strain has resistance to multiple antibiotics such as β-lactams (including carbapenems), aminoglycosides, and ... -
Intracellular passage triggers a molecular response in that increases its infectiousness
(2021)Brucella abortus is a facultative extracellular-intracellular pathogen that encounters a diversity of environments within the host cell. We report that bacteria extracted from infected cells at late stages (48 h post-infection) ... -
Neutrophils as Trojan Horse Vehicles for Brucella abortus Macrophage Infection
(2019-05-07)Brucella abortus is a stealthy intracellular bacterial pathogen of animals and humans. This bacterium promotes the premature cell death of neutrophils (PMN) and resists the killing action of these leukocytes. B. abortus-infected ... -
Manual de Métodos Inmunológicos
(Universidad de Costa Rica. Sede Rodrigo Facio, 2007, 2020)El presente Manual tiene como objetivo proporcionar al lector la información esencial para comprender, ejecutar e interpretar los principales tipos de técnicas inmunológicas básicas en el laboratorio. Las aplicaciones ... -
Técnicas de Laboratorio en Inmunología Clínica
(Universidad de Costa Rica. Sede Rodrigo Facio, 2009, 2009)El presente manual pretende proporcionar al estudiante de la carrera de Microbiología y Química Clínica la información esencial para comprender, ejecutar e interpretar un conjunto de técnicas inmunológicas de aplicación ...
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