Now showing items 1-2 of 2

    • Bacterial Sphingomyelinases and Phospholipases as Virulence Factors 

      Flores Díaz, Marietta; Monturiol Gross, Laura; Naylor, Claire E.; Alape Girón, Alberto; Flieger, Antje (2016-06-15)
      Bacterial sphingomyelinases and phospholipases are a heterogeneous group of esterases which are usually surface associated or secreted by a wide variety of Gram-positive and Gram-negative bacteria. These enzymes hydrolyze ...
    • Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene 

      Alape Girón, Alberto; Flores Díaz, Marietta; Guillouard, Isabelle; Naylor, Claire E.; Titball, Richard; Rucavado Romero, Alexandra; Lomonte, Bruno; Basak, Ajit K.; Gutiérrez, José María; Cole, Steward T.; Thelestam, Mónica (2000-08)
      Clostridium perfringens phospholipase C (PLC), also called α-toxin, is the major virulence factor in the pathogenesis of gas gangrene. The toxic activities of genetically engineered α-toxin variants harboring single ...