Now showing items 1-18 of 18

    • A schizophrenia gene locus on chromosome 17q21 in a new set of families of mexican and central american ancestry: evidence from the NIMH genetics of schizophrenia in latino populations study 

      Escamilla, Michael; Hare, Elizabeth; Dassori, Albana; Peralta, Juan Manuel; Ontiveros, Humberto; Nicolini Sánchez, José Humberto; Medina, Rolando; Mendoza Rodríguez, Ricardo; Muñoz, Rodrigo; Almasy, Laura; Raventós Vorst, Henriette; Jerez, Álvaro (Am J Psychiatry 2009;166:442-449, 2009-02-02)
      The present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders. Method: A genome-wide scan was performed ...
    • Adjudicating Neurocognitive Endophenotypes for Schizophrenia 

      Burk, Gary; Estrada, Jose; Peralta, Juan Manuel; Meyenberg, Naxhielli; Barrett, Jennifer; Nicolini Sánchez, José Humberto; Escamilla, Michael; Glahn, David C.; Almasy, Laura; Blangero, John; Pereira Castro, Mariana; Raventós Vorst, Henriette (American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 144B:242–249 (2007), 2007-03-05)
      Although genetic influences on schizophrenia are well established, localization of the genes responsible for this illness has proven extremely difficult. Given evidence that genes predisposing to schizophrenia may be ...
    • Caracterización de un grupo de pacientes con esquizofrenia en el Valle Central de Costa Rica 

      Montero Vega, Ana Patricia; Dassori, Albana; Escamilla, Michael; Raventós Vorst, Henriette; Contreras Rojas, Javier (AMC, vol 50 (3), julio-setiembre 2008, 2008)
      La esquizofrenia es una enfermedad crónica con importantes repercusiones sociales que afecta al 1% de la población mundial. Se describe las características de la esquizofrenia en una muestra de pacientes del Valle Central ...
    • Diagnosis of Schizophrenia in Latino Populations. A Comparison of Direct Interview and Consensus Based Multi-Source Methods 

      Dassori, Albana; Medina, Rolando; Ontiveros Sánchez de la Barquera, Jose Alfonso; Nicolini Sánchez, José Humberto; Muñoz, Rodrigo; Escamilla, Michael; Contreras Rojas, Javier; Raventós Vorst, Henriette (Journal of Nervous and Mental Disease 2009;197: 530–535, 2009-07)
      We determined the rates of agreement between diagnoses, using the Diagnostic Interview for Genetic Studies (DIGS) and diagnoses arrived at, using additional sources of information, to establish whether there are differences ...
    • Family-based association of an ANK3 haplotype with bipolar disorder in Latino populations 

      Zavala, Juan Manuel; Dassori, Albana; Escamilla, Michael; Raventós Vorst, Henriette; Nicolini Sánchez, José Humberto; Ontiveros Sánchez de la Barquera, Jose Alfonso; Jerez, Álvaro; Contreras Rojas, Javier; Ramírez, Mercedes; Contreras, Salvador; Flores, Deborah; Leach, Robin J.; Armas, Regina; González, S. D. (Translational Psychiatry (2013) 3, e265, 2013-05-28)
      Some of the most consistent findings have been in variants located in the ANK3 (ankyrin-G) gene located on chromosome 10q. Schultz et al.4 found that BP risk alleles in ANK3, rs9804190 and rs10994336, contributed ...
    • Genetic Structure Analysis of Three Hispanic Populations from Costa Rica, Mexico, and the Southwestern United States Using Y-Chromosome STR Markers and mtDNA Sequences 

      Silva de la Fuente, Sandra Maria; Escamilla, Michael; Ontiveros, Humberto; Mendoza Rodríguez, Ricardo; Muñoz, Rodrigo; Raventós Vorst, Henriette; Campos Sánchez, Rebeca; Barrantes Mesén, Ramiro (Human Biology, October 2006, v. 78, no. 5, pp. 551–563., 2006)
      Two hundred seventeen male subjects from Costa Rica, Mexico, and the Hispanic population of the southwestern United States were studied. Twelve Y-chromosome STRs and the HVSI sequence of the mtDNA were analyzed to ...
    • Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder 

      Hare, Elizabeth; Contreras Rojas, Javier; Flores, Deborah; Jerez, Álvaro; Nicolini Sánchez, José Humberto; Ontiveros Sánchez de la Barquera, Jose Alfonso; Almasy, Laura; Escamilla, Michael; Raventós Vorst, Henriette (Journal of Affective Disorders xxx (2011) xxx–xxx, 2011)
      Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. Inthis study, theheritabilities of BPDandtheBig Five personality factors and the ...
    • Heritability of Age of Onset of Psychosis in Schizophrenia 

      Hare, Elizabeth; Glahn, David C.; Dassori, Albana; Raventós Vorst, Henriette; Nicolini Sánchez, José Humberto; Ontiveros Sánchez de la Barquera, Jose Alfonso; Medina, Rolando; Mendoza Rodríguez, Ricardo; Jerez, Álvaro; Muñoz, Rodrigo; Almasy, Laura; Escamilla, Michael (AMERICAN JOURNAL OF MEDICAL GENETICS PART B, 2009-04)
      Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age ofonset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due ...
    • In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation 

      Marballi, Ketan; Quiñones, Marlon; Jiménez, Fabio; Escamilla, Michael; Raventós Vorst, Henriette; Soto Bernardini, María Clara; Ahuja, Seema S.; Walss Bass, Consuelo (J Mol Med (Berl). 2010 November ; 88(11): 1133–1141, 2010-11)
      Neuregulin 1 (NRG1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. Also, recent evidence suggests that NRG1 may play a role in regulation of inflammation and immune ...
    • Meta-analysis of 32 genome-wide linkage studies of schizophrenia 

      Ng, Mandy Y. M.; Levinson, Doug; Faraone, Stephen V.; Suárez, Brian K.; DeLisi, Lynn E.; Arinami, Tadao; Riley, Brien; Paunio, Tiina; Pulver, Ann E.; Irmansyah, Irman; Holmans, Peter A.; Escamilla, Michael; Wildenauer, Dieter B.; Williams, Nigel M.; Laurent, Claudine; Mowry, Bryan J.; Brzustowicz, Linda M.; Maziade, Michel; Sklar, Pamela; Garver, David L.; Abecasis, Gonçalo R.; Lerer, Benjamin; Fallin, Margaret D.; Gurling, Hugh M. D.; Gejman, Pablo V.; Lindholm, Eva; Moises, Hans W.; Byerley, William; Wijsman, Ellen M.; Forabosco, Paola; Tsuang, Ming T.; Hwu, Hai-Gwo; Okazaki, Yuji; Kendler, Kenneth S.; Wormley, Brandon; Fanous, Ayman; Walsh, Dermot; O'Neill, Francis A.; Peltonen, Leena; Nestadt, Gerald; Lasseter, Virginia K.; Liang, Kung-Yee; Papadimitriou, G. M.; Dikeos, D. G.; Schwab, Sybille G.; Owen, Michael J.; O'Donovan, Michael C.; Norton, Nancy; Hare, Elizabeth; Raventós Vorst, Henriette; Nicolini Sánchez, José Humberto; Albus, Margot; Maier, Wolfgang; Nimgaonkar, Vishwajit L.; Terenius, Lars; Mallet, Jacques; Jay, M.; Godard Bauché, Stéphanie; Nertney, Deborah A.; Alexander, M.; Crowe, R. R.; Silverman, Jeremy M.; Bassett, Anne; Roy, M-A.; Mérette, Chantal; Pato, C. N.; Pato, Michele T.; Roos, J. Louw; Kohn, Y.; Amann Zalcenstein, Daniela; Kalsi, G.; McQuillin, Andrew; Curtis, David F.; Brynjolfson, J.; Sigmundsson, T.; Petursson, H.; Sanders, A. R.; Duan, Jubao; Jazin, E.; Myles Worsley, M.; Karayiorgou, Maria; Lewis, Cathryn M. (Molecular Psychiatry (2008), 1–12, Nature Publishing Group, 2008-12-30)
      A genome scan meta analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The ...
    • Methods for treating bipolar mood disorder associated with markers on chromosomes 18p 

      Freimer, Nelson B.; Sandkujil, Lodewijk A.; León Azofeifa, Pedro; Reus, Victor I.; Escamilla, Michael; McInnes, Lynne Allison; Service, Susan K. (1997-08-22)
      The present invention is directed to methods of detecting the presence of a bipolar mood disorder susceptibility locus in an individual, comprising analyzing a sample of DNA for the presence of a DNA polymorphism on the ...
    • Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families 

      Glahn, David C.; Almasy, Laura; Barguil, Marcela; Hare, Elizabeth; Peralta, Juan Manuel; Kent, Jack; Dassori, Albana; Contreras Rojas, Javier; Pacheco, Adriana; Lanzargorta, Nuria; Nicolini Sánchez, José Humberto; Raventós Vorst, Henriette; Escamilla, Michael (Arch Gen Psychiatry. 2010;67(2):168-177, 2010-02-01)
      Context: Although genetic influences on bipolar disorder are well established, localization of genes that predispose to the illness has proven difficult. Given that genes predisposing to bipolar disorder may be transmitted ...
    • Resultados de la categorización de una muestra de pacientes con diagnóstico de egreso de esquizofrenia 

      Montero Vega, Ana Patricia; Balderas, Teresa; Lizano, Arturo; Armas, Regina; Medina, Rolando; Contreras, Salvador; Dassori, Albana; Katz, Israel; Levinson, Doug; Jacques, Jean; Escamilla, Michael; Pereira Castro, Mariana; Raventós Vorst, Henriette (Acta Médica Costarricense, abril-junio 2002, vol 44 (2), 2002-04)
      La esquizofrenia es una enfermedad que afecta aproximadamente al 1% de la población mundial. Es una de las enfermedades psiquiátricas más debilitantes con un alto costo económico, social, familiar y personal. En Costa ...
    • Shared Genetic Factors Influence Risk for Bipolar Disorder and Alcoholism 

      Peralta, Juan Manuel; Almasy, Laura; Contreras Rojas, Javier; Pacheco Arce, Adriana; Escamilla, Michael; Raventós Vorst, Henriette; Glahn, David C.; Carmiol Del Valle, Nasdia (2014-06)
      Bipolar disorder and alcoholism have high rate comorbidity, with more than 50% of alcoholism occurrence in bipolar disorder. While there is evidence that both disorders are heritable, it is unclear if the same genetic ...
    • Substance use disorder and schizophrenia: prevalence and sociodemographic characteristics in the Latin American population 

      Jiménez Castro, Lorena; Raventós Vorst, Henriette; Escamilla, Michael (Actas Esp Psiquiatr 2011;39(2):123-30, 2011)
      El interés por comprender la co-morbilidad de la esquizofrenia y el trastorno en el uso de sustancias, ha aumentado debido al incremento de este diagnóstico, a los efectos negativos observados en el sujeto y a los ...
    • Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in latinos: a family-based association study 

      Xu, Chun; Zavala, Juan Manuel; Armas, Regina; Contreras, Salvador; Dassori, Albana; Ontiveros Sánchez de la Barquera, Jose Alfonso; Nicolini Sánchez, José Humberto; Escamilla, Michael; Ramírez, Mercedes; Flores, Deborah; Jerez, Álvaro; Raventós Vorst, Henriette; González, Suzanne; Leach, Robin J. (Bipolar Disorders 2013: 15: 206–214, 2013-02-25)
      Objectives: Through recent genome-wide association studies (GWASs), several groups have reported significant association between variants in the calcium channel, voltage-dependent, L-type, alpha 1C subunit (CACNA1C) and ...
    • The epsin 4 gene is associated with psychotic disorders in families of Latin American origin 

      Escamilla, Michael; Dae Lee, Byung; Ontiveros Sánchez de la Barquera, Jose Alfonso; Nicolini Sánchez, José Humberto; Mendoza Rodríguez, Ricardo; Muñoz, Rodrigo; Medina, Rolando; Walss Bass, Consuelo; Armas, Regina; Contreras, Salvador; Dassori, Albana; Raventós Vorst, Henriette; Jerez, Álvaro; Figueroa, Andrés; Ramírez, Mercedes (Schizophrenia Research vol. 106, num 2 (2008) 253–257, 2008-10-20)
      This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of families segregating schizophrenia ...
    • The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders 

      Contreras Rojas, Javier; Camarena, Beatriz; Glahn, David C.; Dassori, Albana; Medina, Rolando; Contreras, Salvador; Ramírez, M.; Armas, Regina; Muñoz, Rodrigo; Mendoza Rodríguez, Ricardo; Raventós Vorst, Henriette; Ontiveros Sánchez de la Barquera, Jose Alfonso; Nicolini Sánchez, José Humberto; Palmer, R.; Escamilla, Michael; Hare, L. (Acta Psychiatr Scand 2009: 119: 117–127, 2009-01-11)
      Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether ...