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En busca de un modelo preclínico de la enfermedad de Parkinson. Segunda parte
(1998)
En la Primera parte de este artículo, expuse muy brevemente, algunas de las características de la enfermedad del Parkinson y sobre todo lo difícil que ha sido a lo largo de la historia encontrar una terapéutica realmente ...
Effects of environmental enrichment and social isolation on sucrose consumption and preference: Associations with depressive-like behavior and ventral striatum dopamine
(2008-05)
Little attention has been directed towards environmental control of sensitivity to natural reward and its possible relationship with other motivated behaviors, besides the well-known effects of environmental enrichment and ...
The effect of chronic fluoxetine on social isolation-induced changes on sucrose consumption, immobility behavior, and on serotonin and dopamine function in hippocampus and ventral striatum
(2009-03-02)
This study examined the effect of fluoxetine, a selective serotonin (5-HT) reuptake inhibitor, on isolation-induced changes on sucrose consumption and preference, spontaneous open-field activity, forced swimming behavior, ...
A high performance liquid chromatography method with electrochemical detection of gamma-aminobutyric acid, glutamate and glutamine in rat brain homogenates
(2009)
Determination of γ-aminobutyric acid (GABA), glutamate (Glu) and glutamine (Gln) in animal models has been important to understand the normal function and clinical aspects of some neurological diseases. Quantification of ...
Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum
(2008)
Dawley rats were reared from weaning in either social isolation, standard laboratory conditions, or environmental enrichment. Open-field activity
was assessed at postnatal days 37, 65, 93 and 107 and 1 h before the last ...
Behavioral and neurochemical characterization of maternal care effects on juvenile Sprague–Dawley rats
(2013)
Maternal care represents a major constituent of early life environment and has the potential to modulate critical
neurobehavioral responses to stress. The aim of the present study was to determine the effects of naturally ...
Maternal behavior as an early modulator of neurobehavioral offspring responses by Sprague-Dawley rats
(2013)
Maternal care plays an important role as an early modeler of neurodevelopment and brain function,
and its effects remain until adulthood. Such modeling or programming has shown to influence the
stress response and ...
Neurociencias y Psicologíaen Costa Rica: Programa de Investigación en Neurociencias
Neuroscience and Psychology in Costa Rica: Neuroscience Research Program
(2012)
El presente artículo es una reseña histórica del Programa de Investigación en Neurociencias(PIN) de la Universidad de Costa Rica, que fue creado en el año 1999. Actualmente,está organizado en tres áreas de investigación: ...
Enfermedad de Alzheimer: Modelos animales como una alternativa para entender la patología y buscar estrategias terapéuticas más exitosas
Alzheimer's disease: Animal models as an alternative to understand the pathology and to search more successful therapeutics.
(2013-07)
La enfermedad de Alzheimer (EA) es la enfermedad neurodegenerativa más frecuente en el mundo; su incidencia aumenta ante una mayor esperanza de vida en muchos países. La caracterizan tres eventos histopatológicos principales: ...