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dc.creatorRamírez Chan, Karol Gabriela
dc.creatorQuesada Yamasaki, Daniel
dc.creatorFornaguera Trías, Jaime
dc.date.accessioned2018-12-11T18:11:24Z
dc.date.available2018-12-11T18:11:24Z
dc.date.issued2019-01-01
dc.identifier.citationhttps://revistas.ucr.ac.cr/index.php/Odontos/article/view/35510/36112es_ES
dc.identifier.issn1659-1046
dc.identifier.urihttps://hdl.handle.net/10669/76272
dc.description.abstractLipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria. In animals, intraperitoneal administration of LPS, stimulates innate immunity and the production of pro-inflammatory cytokines. LPS provides an inflammatory stimulus that activates the neuroimmune and neuroendocrine systems resulting in a set of responses termed sickness behavior. The purpose of this protocol is to describe step-by-step the preparation and procedure of application of intraperitoneal injection of LPS in rats, as a guide for those researchers that want to use this assay to mount an inflammatory response. LPS intraperitoneal challenge in rats has been widely used to evaluate anti-inflammatory reagents and to address basic scientific questions.es_ES
dc.description.sponsorshipFondo de Estímulo dado a Karol Ramírez Chanes_ES
dc.language.isoen_USes_ES
dc.sourceOdovtos International Journal of Dental Sciences, Vol 21 No 1, 2019es_ES
dc.subjectLipopolysaccharidees_ES
dc.subjectLPS challengees_ES
dc.subjectLPS stimulationes_ES
dc.subjectEndotoxines_ES
dc.subjectInflammationes_ES
dc.titleA Protocol to Perform Systemic Lipopolysacharide (LPS) Challenge in Ratses_ES
dc.title.alternativeProtocolo para realizar reto sistémico con lipopolisacárido (LPS) en ratases_ES
dc.typeartículo científicoes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Odontologíaes_ES


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