Anti-inflarnmatory activity of Urera baccifera (Urticaceae) in Sprague-Dawley rats
Cargando...
Fecha
Authors
Badilla Baltodano, Beatriz
Mora, Gerardo A.
Lapa, Antonio José
Silva Ernim, José Arthur
Título de la revista
ISSN de la revista
Título del volumen
Editor
Universidad de Costa Rica
DOI
Resumen
Descripción
On a preliminary test, anti-inflammatory and analgesic dose-related activities on rats were observed for the aqueous fraction of Urera baccifera; this extract was bioassay-guided fractionated and the final aqueous fraction was used according the ethnobotanical use. Carrageenan-induced edema (n=6), was used as an assay in the fractionating process. The anti-inflammatory and antinociceptive properties of the final aqueons fraction were studied using in vivo models. For the anti-inflammatory activity rat paw edema (n=6), pleurisy induced by carrageenan (n=6) and ear edema induced by topical croton oil (n=6) models were used, and tail-fIick test (n=6), abdominal constrictions induced by acetic acid (n=6), and formalin test (n=6), were used for the alltillociceptive activity. The tests perfonned showed an inhibition effeet on !eukocyte rnigration, and a reductioll on pleural exudate, as well as dose-dependant peripheral analgesic activity, al a range of 25-100 mglk:g i.p. The final aqueous fraction contains most of the anti-inflammatory activity of the plant U. baccifera. A possibJe mechanism of action is discussed and based on the results we conclude that this plant has a potential. for both anti-inflammalory and analgesic activity al the c1inical level.
Palabras clave
Citación
Colecciones
Aprobación
Revisión
Complementado por
Referenciado por
Rights and licensing
Copyright (c) 2015 International Journal of Tropical Biology and Conservation