Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms

Sánchez Brenes, Andrés; Coto Porras, Jorge; Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; Solano Trejos, María Gabriela; Herrera Vega, María; Villalta Arrieta, Mauren; Estrada Umaña, Ricardo; Gutiérrez, José María

doi:https://doi.org/10.1016/j.toxicon.2015.10.001

Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms

Archivos

407_2015_Toxicon_Sánchez_antivenoms_geographic_variation.pdf (317,3 KB)

Fecha

2015-12-15

Authors

Sánchez Brenes, Andrés

Coto Porras, Jorge

Segura Ruiz, Álvaro

Vargas Arroyo, Mariángela

Solano Trejos, María Gabriela

Herrera Vega, María

Villalta Arrieta, Mauren

Estrada Umaña, Ricardo

Gutiérrez, José María

DOI

https://doi.org/10.1016/j.toxicon.2015.10.001

Resumen

Two antivenoms prepared by using Echis ocellatus, Bitis arietans and Naja nigricollis venoms from different locations in sub-Saharan Africa were compared for their neutralizing ability. Both antivenoms were similarly effective in the neutralization of the venoms of the three species from different locations. However in the case of E. ocellatus venom, antivenom prepared using venom from Nigerian specimens was more effective than antivenom prepared with venom from Cameroon specimens in the neutralization of coagulant activity.