Ability of the phospholipase A2 inhibitor Varespladib to abrogate or delay lethality induced by neurotoxic snake venoms

Abstract

This study investigated the ability of the phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its oral prodrug, methyl-Varespladib (LY333013), to abrogate or delay the lethality induced by potent neurotoxic snake venoms in a mouse model. The venoms tested were from Oxyuranus scutellatus, Notechis scutatus, Bungarus multicinctus, and Crotalus durissus terrificus, all known for having potent neurotoxic PLA2s.