Family-based association of an ANK3 haplotype with bipolar disorder in Latino populations

Abstract

Some of the most consistent findings have been in variants located in the ANK3 (ankyrin-G) gene located on chromosome 10q. Schultz et al.4 found that BP risk alleles in ANK3, rs9804190 and rs10994336, contributed independently to BP with no significant marker–marker interaction. we have designed a family-based association study to evaluate single-nucleotide polymorphisms (SNPs) spanning the ANK3 gene, including GWAS-significant SNPs rs9804190 and rs10994336, in 215 Latino pedigrees with reported ancestry from Mexico or Central America. All study participants were diagnosed using Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria using a best-estimation consensus procedure as previously described.7 Of the 929 individuals in this study, 466 were diagnosed with BPI and 16 were diagnosed with SABP.